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• Second leading systemic cancer with CNS metastases – 10-16% • Characteristics of CNS disease • Site is much more likely to be parenchymal than leptomeningeal • Neurological symptoms typically reason for discovery • More likely to be in setting of progressive systemic disease* • Risk is not equal among the breast cancer subtypes • HER-2 positive • Triple negative (ER neg, PR neg, and HER-2 neg) • Mechanism and outcomes are not the same among风险最高的人•HER-2正•三重负面（er neg，pr neg和her-2 neg）
中枢神经系统转移的管理
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