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draft-em-1st-Amendment-rpo-regulations-2023-1.pdf
(MU) Gross Energy Consumption 4948.94 3283.55 3622.49 Non-Solar RPO Target 570.27 377.61 416.59 Non-Solar RPO Achieved 571.95 0 529.77 Non-Solar RPO Shortfall/Surplus (1.68) 377.61 (113.18) Solar RPO Target 173.21 147.76 217.35 Solar RPO达到172.36 38.46 217.61 Solar RPO短缺 /盈余0.85 109.3（0.26）总RPO目标743.48 525.37 637 633.94总RPO达到了744.31 38.31总计46 746 747.38 Surpo surpo （113.44）累积RPO短缺/（盈余）（10.35）476.56 363.12
成人2型糖尿病
Offer daily statin if QRISK2 or 3 ≥ 10% after addressing modifiable risk factors (see page 7 for clinical condition variations between Qrisk 2 and 3) Atorvastatin 20mg – (or maximum tolerated dose) [alternative is rosuvastatin 10mg] If after 3 months not achieved ≥ 40% reduction in non-HDL cholesterol from baseline, consider up titration of statin to a maximum dose of Atorvastatin 80mg [替代性是Rosuvastatin 20mg]，如果不容忍更高剂量，请考虑每天添加10mg的ezetimibe。如果不耐汀类药物（开始Ezetimbe），请参考脂质诊所。如果非HDL胆固醇仍未达到≥40％的降低，请参见心血管疾病患者的脂质诊所，请参见二级预防。中风，PVD，CHD
![arxiv：2012.15318v1 [eess.iv] 2020年12月30日](/simg/g:\will\search\icon\source\7\7371e2d3d1855378e227bef0191c9de17a2e6d4c.webp)
arxiv：2012.15318v1 [eess.iv] 2020年12月30日
摘要。在本文中，我们提出了一个混合高分辨率和非局部特征网络（H 2 NF-NET），以分割多模态MR图像中的脑肿瘤。我们的H 2 NF-NET使用单个和级联的HNF-NET来分割不同的脑肿瘤子区域，并将预定剂结合在一起作为最终分割。我们培训并评估了我们的模型关于多模式脑肿瘤分割挑战（BRATS）2020数据集。The results on the test set show that the combination of the single and cascaded models achieved average Dice scores of 0.78751, 0.91290, and 0.85461, as well as Hausdorffdistances (95%) of 26.57525, 4.18426, and 4.97162 for the enhancing tumor, whole tumor, and tumor core, respectively.我们的方法赢得了近80名参与者的Brats 2020挑战细分任务的第二名。
对蛋白质生物标志物的敏感多路复用定量，用于早期药物发现和发育
Sensitive multiplexed quantification of protein biomarkers for early drug discovery and development Increasing sensitivity for quantification of surfactant proteins in matrix using the SCIEX 7500 system Bo An 1 , Timothy Sikorski 1 , John Mehl 1 , Eshani Nandita 2 , Remco van Soest 2 and Elliott Jones 2 1 Glaxosmithkline, Upper Providence, Pennsylvania; 2 Sciex，加利福尼亚州红伍德城，该技术说明使用高端三倍四极杆质谱仪在签名肽水平上对表面活性剂蛋白的高度敏感定量工作流程。通过改进的前端技术，可以在Sciex 7500系统上生成，捕获和传输更多离子，从而增强了表面活性剂蛋白的敏感性。Low-ng/mL lower limits of quantification (LLOQs) were achieved for the 4 surfactant proteins analyzed in human plasma.
供应链通讯版2 UPD
作为KNK转型的一部分，我们实施了一个标准的操作程序，以管理与利益相关者（内部和外部）的互动，并倾听了包括石油委员会和供应商社区在内的利益相关者的反馈，以推动我们流程的持续改进。我们还更新了我们的小组合同和采购程序（GCPP），以与全球最佳实践保持一致。In 2022, we achieved greater transparency by awarding more contracts to local and JV companies, introducing the supplier mentorship program through which we trained 97 indigenous companies and onboarded an additional 90 companies onto our Supply Chain Academy Programme, and identified two additional business sectors (fabrication scopes and blending & testing of wells) to be considered for indigenization over the next two years.在此过程中，我们为加纳当地内容开发的贡献而赢得了今年的两个本地内容奖。
综合年度报告2024
自2020年以来（以下简称该集团，企业或公司）采用了综合方法来报告财务绩效以及环境，社会和治理（ESG）信息，目的是在单个文档中提供完整，可衡量的和透明的价值观。The Integrated Annual Report describes in fact the development strategies of Leonardo, driven by the vision for the next years expressed in the Industrial Plan, and the performance achieved, the way in which the company creates innovative solutions with its supply chain partners and the scientific research ecosystem, operating responsibly in the countries where it is present, and enhancing the value of all its capital, people and expertise, technology and intellectual property, financial resources, industrial assets, relations and伙伴关系，能源和自然资源。
快速参考指南 - 临床实践指南
Pregnancy should be planned, with the following steps taken prior to conception: • A1C 7% or less, but strive for ≤6.5% (ensure contraception until at personalized target) • Stop: - Non-insulin antihyperglycemic agents (except metformin and/or glyburide) - Statins - ACEi/ARB prior to pregnancy, but if overt nephropathy exists, continue until detection of pregnancy • Start: - Folic acid 1 mg per day x 3 months prior to conception - Insulin if target A1C is not achieved on metformin and/or glyburide (type 2) - Other antihypertensive agents safe for pregnancy (Labetalol, nifedepine XL) if hypertension control needed • Screen for complications: - Eye appointment, serum creatinine, urine ACR, blood pressure • Aim for healthy BMI • Ensure appropriate vaccinations have发生•参考糖尿病诊所
快速参考指南 - 临床实践指南
Pregnancy should be planned, with the following steps taken prior to conception: • A1C 7% or less, but strive for ≤6.5% (ensure contraception until at personalized target) • Stop: - Non-insulin antihyperglycemic agents (except metformin and/or glyburide) - Statins - ACEi/ARB prior to pregnancy, but if overt nephropathy exists, continue until detection of pregnancy • Start: - Folic acid 1 mg per day x 3 months prior to conception - Insulin if target A1C is not achieved on metformin and/or glyburide (type 2) - Other antihypertensive agents safe for pregnancy (Labetalol, nifedepine XL) if hypertension control needed • Screen for complications: - Eye appointment, serum creatinine, urine ACR, blood pressure • Aim for healthy BMI • Ensure appropriate vaccinations have发生•参考糖尿病诊所
MRK.N-默克公司Inc. Investor活动在ASCO
我们还拥有ADC候选2870，现在称为SAC-TMT。和在围手术期的环境中，某些患者即使受益于KeyTruda，他们仍然处于重复的高风险。These patients can potentially benefit from more intensive therapy while avoiding the level of treatment intensity for those patients who don't need it.因此，如果您查看Keynote-671示例，我们的患者已经实现了病理完全反应，而那些没有。And so the idea here with MK-2870 is those patients who have not achieved pathologic complete response and have very high event rates, even with KEYTRUDA, which improves outcomes quite a bit in this population, now, we can add 2870 and hopefully improve their outcomes for there.
气候变化问责制报告-UBC可持续性
As a commitment to advance toward these CAP 2030 targets, the campus had put great efforts in 2023 to continue reducing operational GHG emissions such as UBC's Major Capital Projects process kick-off for the electric boiler and thermal energy storage project for transitioning the academic District Energy System (DES) to 100% clean and renewable energy, a number of heating and cooling control enhancement projects, and the Gateway building project which achieved the Canada Green Building Council's Zero碳建筑设计认证和寻求LEED金认证，旨在达到低操作排放和大幅减少体现碳。绿色建筑行动计划（GBAP）下的气候就绪要求（包括具体的碳减少途径）将进一步以这些成功为基础。UBC的贡献得到了公共部门领导碳领导力论坛的认可，以帮助绘制减少碳减少的途径。