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2021; 12(15): 4710-4721。doi: 10.7150/jca.58873 研究论文 MicroRNA-455-5p 促进胆管癌生长并介导高良姜素的抗 T
充分了解胆管癌 (CCA) 的发展机制和发现有希望的治疗药物对于延长患者的生存时间至关重要。本研究发现，microRNA-455-5p (miR-455-5p) 靶向蛋白磷酸酶 1 调节亚基 12A (PPP1R12A)，其可抑制丝裂原活化蛋白激酶 (MAPK) 和 PI3K/AKT 通路激活，从而控制 CCA 细胞存活和转移。此外，miR-455-5p 在 CCA 组织中的表达降低并与 PPP1R12A 呈负相关，PPP1R12A 敲低表型模拟 miR-455-5p 对 CCA 细胞的影响。此外，我们证明高良姜素在体内和体外均抑制 CCA 生长，这与 miR-455-5p 增加和 PPP1R12A 表达抑制有关。进一步证明，miR-455-5p 的过度表达可消除高良姜素介导的抗 CCA 作用。这些发现确立了 miR-455-5p 在 CCA 发展中的重要作用，而高良姜素可能为抗 CCA 治疗提供潜在的治疗辅助剂。
Supporting Skills Development for Economic Transformation in Rwanda (SD4T)
SD4T contributes to improving the quality of TVET for the light manufacturing sector through better alignment with industry needs and practical training within companies. This includes fos- tering collaboration and innovation among stakeholders at dis- trict level where SD4T supports the actors in implementing own solutions, jointly solving challenges related to local marketing and skills development. Additionally, this includes organizing work- place learning for TVET students, facilitating the development or revision of curricula by industry practitioners together with TVET academics and supporting TVET teachers in enhancing their com- petencies. Moreover, short courses for upgrading skills of already employed staff from light manufacturing companies are offered. The programme collaborates closely with Rwanda Polytechnic (RP) and the Rwanda TVET Board (RTB) and supports those insti- tutions in their mandates. It also contributes to their efforts to- wards increased use of digital tools and access to learning materi- als for TVET pedagogy.
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At Reed Global Limited's ("Reed's") core is a long history of pioneering environmental action, with Reed holding CarbonNeutral® status since 2005.We consider ourselves a PhilCo, “Philanthropy Company” because 18% of our company is owned by the Reed Foundation, which contributes vital funds to charities solving some of the world's biggest problems, multiplying impact through the Big Give.
植物环境相互作用（C003095）
本课程构成了成功完成课程“植物生理学”（生物化学和生物技术学学士学位）和“植物分子生物学”（第3次生物化学和生物技术学士学位）后获得的知识和能力。它构成了课程“植物生长和开发”和“植物工厂”的基础。该课程的目的是在植物的内部和外部交流网络中获得深刻的见识。This course contributes to following program competences: Ma.WE.BB.1.1, 1.2, 1.3, 1.4, 1.5 Ma.WE.BB.2.1, 2.2, 2.3, 2.4, 2.5, 2.6 Ma.WE.BB.3.1, 3.2, 3.3, 3.4, 3.5, 3.6 Ma.WE.BB.4.1, 4.2, 4.3, 4.4 Ma.WE.BB.5.1 ma.we.bb.6.1，6.2 ma.we.bb.7.res1，7.Res2
引用本文：de la Fuente J，Bedia J，GortázarC。Covid-19的视觉交流和学习，以提高对Pandemics的准备。 Explor
目前正在进行的冠状病毒19（Covid-19）大流行已影响全球人类健康和经济。正在进行的研究表明，事实与该疾病有关，并提出了与疾病控制和预防有关的问题。In this perspective, the collaboration between science and art in visual communication using the artwork “Enseñanza” (“Teaching”) contributes to the representation of the lessons learned from COVID-19 and the way forward.To advance preparedness for current and future pandemics, the authors propose to address international collaborations, support to science, access to food supplies and health services, sustainable development and a “One Health” approach searching a balanced interaction of humanity with nature and a more holistic approach to disease prevention and control.
材料的力学
在课程结束时，学生将能够：·使用模型来解决基本问题，允许预测有限菌株和裂纹繁殖的材料的机械响应以及（超级）弹性和（visco）可塑性，以解释每个模型的基本物理，以及每个模型的基础，以及微观结构和材料之间的弹性弹性，以解释各种弹性，以解释各种元素，以解释各种主题的构成，以下各种现象的构成，构成了各种现象的构成，构成了启动的构成。塑料变形的样品，残留应力和蠕变的背部和颈部。· to select a material with the best combination of mechanical properties based on the definition of performance indices, According to the classification of LO in the EPL programme, this activity contributes to the development and acquisition of the following LO: LO1.1, LO1.2, LO1.3, LO2.1, LO2.2, LO2.4, LO5.3, 5.4, 5.6
加利福尼亚大学圣地亚哥分校
图1：新生儿GBS感染中肺损伤的死亡率和持续性增加。40图2：肺部炎症和GBS清除的延迟动力学在新生儿GBS肺炎中肺泡巨噬细胞清除率................................................................................................................................................................................................................................................................................................................................................................................................................................................. Figure 4: Developmental Maturation of Lung Myeloid Siglec Expression ............................ 46 Figure 5: Developmental Immaturity of AM Siglec-Sialic Acid Detection Contributes to Neonatal GBS Susceptibility ................................................................................................... 48 Figure 6: Sn Expression Declines Over Time Following GBS Infection ............................... 51 Figure 7: The Sia-Siglec-E Interaction Mediates Decreased Sn Expression Following Infection ................................................................................................................................... 53 Figure 8: Siglec1 is Regulated by the STAT Pathway and is Differentially Accessible in the Adult .................................................................................................................................. 55 Figure 9.RG, IFN- , Did Not Increase Sn Expression on the First Day of Life .................. 57 Figure 10: Sialic Acid is Not Expressed in the Developing Fetal Lung ................................. 59
幼儿学习轨迹：证据基础
每个轨迹都将域将域的域拆除到其复合子域和链中，并为描述学习方式的每个链规定了4个指标。教师和教育工作者可以使用指标将他们在游戏和日常工作期间对儿童学习的观察重点，并解释他们的观察和评估。系统地使用学习轨迹也可能支持教师和教育者专业学习。Each domain contributes to the learning outcomes of the Early Years Learning Framework (EYLF, EYLF V2.0) (Department of Education, Employment and Workplace Relations [DEEWR], 2009; Australian Government Department of Education [AGDE], 2022) and Victorian Early Years Learning and Development Framework (VEYLDF) (Victorian Department of Education and Training [DET VIC] & Victorian Curriculum and Assessment Authority [VCAA], 2016）。本报告借鉴了原始EYLF和修订版，EYLF v2.0于2023年1月发布。
卢旺达国家 - 计划策略
As such the implementation of the IUCN Rwanda Strategy contributes directly to the four goals of the Post-2020 Global Biodiversity Framework which are: • Goal A The integrity of all ecosystems is enhanced, with an increase of at least 15 per cent in the area, connectivity and integrity of natural ecosystems, supporting healthy and resilient populations of all species, the rate of extinctions has been reduced at least tenfold, and the risk of species所有分类和官能团的灭绝，一半，野生和驯养物种的遗传多样性得到保护，在所有物种中，至少有90％的遗传多样性。•目标b自然对人的贡献是通过保护和可持续用途的重视，维护或增强的，从而支持全球发展议程，以使所有人受益。•目标c利用遗传资源所带来的收益公平，公平地共享，货币和非货币福利共享，包括保护和可持续使用生物多样性
职位描述
______________________________________________________________________ Main purpose of job To be responsible to the Neighbourhood Services Manager for the overall management, implementation and evaluation of the Local Biodiversity Action Plan (LBAP) for Belfast, and ensuring it is aligned with and contributes to national and international biodiversity targets and strategies.确保理事会意识到并履行其在现行和即将到来的相关立法下的义务和义务。确保理事会是保护和增强贝尔法斯特内生物多样性的主要参与者，并为外部组织提供有关生物多样性问题的适当游说。建立，维护和管理一系列战略合作伙伴关系，以确保在政府部门和机构，理事会工作人员，地方组织，社区，企业和个人等兴趣方面的参与计划，以保护和增强生物多样性。促进和提高整个贝尔法斯特的生物多样性及相关问题的认识，以提高对潜在影响贝尔法斯特的问题的适当意识，并管理和为与生物多样性相关的产品提供支持。向理事会部门，公园工作人员和外部组织提供建议，例如自然保护小组和土地所有者，包括现场管理在内的生物多样性问题。