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M.Sc.时尚和服装设计选择... 计算机应用学士学位2023 - 2026 ...M.Sc.时尚和服装设计选择...计算机应用学士学位2023 - 2026 ...
学生学生学生很少学生从未主动主动为有助于贡献班级做出贡献，并通过班级按班级按班级按课堂询问班级，从而提出想法，为您提供想法的想法，偶尔提供想法，并提出
与普通人群相比，最近到达瑞典Scania的糖尿病的糖尿病风险因素
本综述研究了PIN1在癌症发展和治疗中的复杂作用。PIN1是唯一可以识别并同构化磷酸化的Ser/Thr-Pro肽键的肽基 - 丙酰异构酶（PPIASE）。PIN1催化磷酸化的Ser/Thr-Pro基序的结构变化，该基序可以调节蛋白质功能，从而影响细胞周期调节和肿瘤发生。The molecular mechanisms by which Pin1 contributes to oncogenesis are reviewed, including Pin1 overexpression and its correlation with poor cancer prognosis, and the contribution of Pin1 to aggressive tumor phenotypes involved in therapeutic resistance is discussed, with an emphasis on cancer stem cells, the epithelial-to-mesenchymal transition (EMT), and immunosuppression.在鉴定有效的，类似药物的小分子PIN1抑制剂方面，讨论了PIN1抑制在癌症中的治疗潜力。可用的证据通过分析PIN1在复杂的癌症驾驶途径的复杂网络中的作用，并说明使用PIN1抑制剂治疗侵袭性和药物抗药性肿瘤的潜在，将PIN1的作用通过分析PIN1在复杂的癌症驾驶途径的复杂网络中的作用，来支持靶向PIN1作为新型癌症治疗的效率。
机器人能力，自治和...
Abstract —Human trust in social robots is a complex attitude based on cognitive and emotional evaluations, as well as a behavior, like task delegation.While previous research explored the features of robots that influence overall trust attitude, it remains unclear whether these features affect behavioral trust.Additionally, there is limited investigation into which features of robots influence cognitive and emotional attitudes, and how these attitudes impact humans' willingness to delegate new tasks to robots.This study examines the interplay between competence, autonomy, and personality traits of robots and their impact on trust attitudes (cognitive and affective trust) and trust behavior (task delegation), within the context of task-oriented Human- Robot Interaction.我们的发现表明机器人能力是信任的关键决定因素，影响认知，情感和行为信任。相比之下，机器人人格特征只会显着影响情感信任，而不会影响认知信任或信任行为。In addition, autonomy was found to moderate the relationship between competence and cognitive trust, as well as between personality and affective trust.最后，发现认知信任会积极影响任务授权，而情感信任并未显示出显着影响。This paper contributes to the literature on Human-Robot Trust by providing novel evidence for the design of robots that can interact effectively with humans and enhance their trust.
通过基因组编辑实现高产不褐变茄子
褐变会损坏水果和蔬菜并造成食物浪费。不褐变则保留了水果和蔬菜的感官营养特征和食品品质。我们的研究有可能提高作物的市场价值，因为不褐变会增强人们的视觉感知和食欲，使作物更容易被消费者接受。切片后不褐变可锁住其风味和营养价值。产量增加（超过对照的 10%）有助于提高茄子的总产量。开发具有理想特性的基因组编辑作物主要通过提高产量、提供安全食品和减少食物浪费来促进粮食安全。
通过抑制 P 糖蛋白介导的药物耐受持久细胞中有毒脂质过氧化副产物的清除，有效靶向治疗乳腺癌
Therapy resistance has long been considered to occur through the selection of pre-existing clones equipped to survive and quickly regrow, or through the acquisition of mutations during chemotherapy. Here we show that following in vitro treatment by chemotherapy, epithelial breast cancer cells adopt a transient drug tolerant phenotype characterized by cell cycle arrest, epithelial-to-mesenchymal transition (EMT) and the reversible upregulation of the multidrug resistance (MDR) efflux transporter P-glycoprotein (P-gp). The drug tolerant persister (DTP) state is reversible, as cells eventually resume proliferation, giving rise to a cell population resembling the initial, drug-naïve cell lines. However, recovery after doxorubicin treatment is almost completely eliminated when DTP cells are cultured in the presence of the P-gp inhibitor Tariquidar. Mechanistically, P-gp contributes to the survival of DTP cells by removing reactive oxygen species-induced lipid peroxidation products resulting from doxorubicin exposure. In vivo, prolonged administration of Tariquidar during doxorubicin treatment holidays resulted in a significant increase of the overall survival of Brca1 − / − ;p53 − / − mammary tumor bearing mice. These results indicate that prolonged administration of a P-gp inhibitor during drug holidays would likely benefit patients without the risk of aggravated side effects related to the concomitantly adminis tered toxic chemotherapy. Effective targeting of DTPs through the inhibition of P-glycoprotein may result in a paradigm shift, changing the focus from countering drug resistance mechanisms to preventing or delaying therapy resistance.
INTA 8000-A 科学、技术和国际事务 I（又名技术和国际安全）
学习目标 学生将能够识别关于不同类别军事技术的持久和新兴战略辩论。 学生将学习应用国际关系理论来分析军事技术的宏观战略背景。 本课程有助于实现以下 MS IAST 学习成果：“4. 学生将培养研究技能，以便就国际事务中的特定技术和科学问题撰写研究或政策论文。” 本课程还有助于实现以下 INTA PhD 学习成果：“4. 学生将能够应用高级研究技能撰写可发表的研究成果，为技术和国际事务方面的学术著作做出贡献。” 这些学习成果将通过学期论文进行评估。
Kohoku Kogyo Co。，Ltd
通过与铝电解电容器的铝箔成分相似的方式在铅末端的表面上应用氧化物膜处理，铅末端也起着介电功能，并有助于铝电解电容器的容量扩展。由于氧化物膜区域的高成形特征和高精度，它也有助于铝电解电容器的产量提高。
第 6 节：机场改进利用绿色...
• 比化石燃料产生更少的生命周期排放量；• 可以补充购买不可再生能源；• 可以降低运营成本；• 可以减少机场的碳足迹；• 可以降低电力供应的不确定性；• 有助于遵守法规；• 提供创收潜力；• 提供潜在的当地空气质量效益；• 有助于提高气候适应力。
靶向邻育素-2进行心力衰竭基因治疗
传记：朗兴（Long-Sheng）博士是爱荷华大学卡佛大学医学院（University of Iowa Carver College）心血管研究的教授兼伊迪丝·金·皮尔森（Edith King Pearson）主席。宋博士是国际心脏研究学会的当选研究员，是心脏激发 - 收缩（E-C）耦合方面的领先专家。他在高影响力期刊上撰写了120多个同行评审的出版物，包括科学，自然，细胞，流通等。他的研究为了解健康和疾病（包括心力衰竭和心律不齐）的E-C耦合做出了重大贡献。Notably, Dr. Song's work uncovered how ultrastructural remodeling of cardiomyocyte T-tubule system contributes to E-C coupling dysfunction and heart failure (PNAS, 2006) and how these changes are linked to the dysregulation of junctophilin-2, a key structural protein in E-C coupling (Circulation Research, 2010; PNAS, 2014; Circulation, 2014).在其具有里程碑意义的2018年科学论文中，Song博士证明了Calpain裂开的N末端片段的N末端片段可作为应激自适应的转录调节剂，可以防止在压力心脏中进行转录重编程和病理重塑。这一发现为心力衰竭的精确医学和有针对性的治疗策略开辟了新的途径（Circulation Research，2022； Cockulation，2024）。此外，Song的研究还提高了对心律不齐的理解，包括心房颤动（循环，2023； Heart Rhythm，2024），心律失常右心肌病（循环，2020年）和儿童素疗法多肌膜多态性的心态心态循环。