XiaoMi-AI文件搜索系统
World File Search Systemsigni
亚利桑那州健康改善计划
亚利桑那州的健康改善计划提供了一个结构和一个场所，将合作伙伴的网络系统汇总在一起，以改善亚利桑那州的社区和个人的健康。由da ta and Communi ty ty ty参与，包括构成公共卫生系统的个人和组织。该计划通过增强非交易党的IPS，焦点，对prio an eas and eas，bre aking s ilos以及利用社区健康改善计划（chips）在全州范围内进行了研究。通过确定特定于亚利桑那州需求的优先级，该计划可以对促进健康和疾病的预防产生最大的影响。第一个计划SP 2016-2 020 and Descr介绍了如何使她陷入困境，以解决她的四个跨切问题和13个健康优先事项，以解决signi
1型小儿糖尿病患者中血糖控制的预测因子 - 埃塞俄比亚东北部
结果：在203例1型糖尿病患者中，平均年龄为8.72±4.25岁，最大的参与者组为10岁以上（77例患者，37％）。大多数患者是女性，总计126（62.1％），约69（34.0％）在7 - 10年级。视网膜病，肾病和糖尿病性酮症酸中毒。超过一半的患者，107（52.7％）具有良好的糖尿病控制，而96（47.3％）的糖尿病控制差。Factors signi fi cantly associated with poor glycemic control include having diabetes for more than 5 years (aOR: 1.45; 95% CI: 0.47, 0.91), being a third-born child (aOR: 0.22; 95% CI: 0.05, 0.92), having a comorbid disease condition (aOR: 1.84; 95% CI: 0.29, 0.92), and experiencing与糖尿病有关的并发症（AOR：0.26; 95％CI：0.08，0.97）。
crispr/cas9介导的黄豌豆中的脂氧合酶基因编辑导致脂肪酸和脂肪酸的主要变化
结果与讨论：通过野生型（WT）和TGP PSLOX2突变型线的DNA测序确定了稳定转基因PEA系（TGP）的成功CRISPR/CAS9介导的LOX基因编辑（TGP）。还评估了这些线路的LOX活性，PUFA水平和VOC。Compared to WT peas, the TGP lines showed a signi fi cant reduction (p < 0.05) in LOX activity and in the concentration of key VOCs, including hexanal, 2-hexenal, heptanal, (E)-2-heptenal, (E,E)-2,4- heptadienal, 1-octen-3-ol, octanal, (E)-2-octenal （E，E）-2,4-非二烯和Furan-2-苯基。在TGP浮动中，两个必需的PUFAS，亚油酸和二酚酸的含量是LOX的已知底物，表明CRISPRPR介导的基因编辑的效率在最小化其氧化和PUFAS及其产品的进一步调节方面具有效率。vocs的集合
长k-mers的简单有效采样算法
Next-generation sequencing (NGS) has emerged as a pivotal tool in precision medicine in oncology by enabling analysis of multiple genes at once and facilitating the detection of low-frequency mutations in patients, which may be implicated in treatment resistance, thereby underscoring the clinical significance of NGS in therapeutic decision- making ([5, 6]).然而，能够分析测序数据以识别突变的自由可用的开源软件工具的稀缺对生物学家构成了一个显着的挑战，而未经生物信息学培训。例如，最近描述的工具，即rNalut软件，迅速检测到突变并显示其频率，但缺乏功能，使用户可以理解和修改用于选择高质量读取的参数，或者指定最小的等位基因频率（VAF）以进行报告突变（[4]）。此外，缺乏有关用于比较的参考序列的披露是一个关键限制，尤其是对于随后对识别突变的功能研究。
5年疗效和生物标志物来自Checkmate 238
ABSTRACT ◥ Purpose: In the phase III CheckMate 238 study, adjuvant nivo- lumab signi fi cantly improved recurrence-free survival (RFS) and distant metastasis-free survival versus ipilimumab in patients with resectedstageIIIB – CorstageIVmelanoma,withbene fi tsustainedat 4 years.我们报告了更新的5年效率和生物标志性发现。患者和方法：由阶段和基线编程的死亡细胞配体1（PD-L1）表达进行分层的IIIB - C/IV型黑色素瘤的患者，并每2周接受Nivolumab 3 mg/kg或接受Nivolumab 3 mg/kg，或者每3周每3周一次ipiLimumAb每3周一次撤回每12周，然后每3周，均可恢复1年，直到有毒性，直到有疾病，直到有疾病，直到有疾病。主要终点是RFS。结果：在62个月的最小随访中，具有Nivolumab的RF仍然优于ipilimumab（HR¼0.72; 95％的置信间隔，0.60 - 0.86； 5年50％比39％）。五个 -
![arxiv：2502.00486v1 [cs.ce] 2025年2月1日](/simg/6\607920211e1a773fea6e3daecbcc0066edddd62f.webp)
arxiv：2502.00486v1 [cs.ce] 2025年2月1日
Abstract Hindcast or Wave Reanalysis Data Bases (WRDB) constitute a pow- erful source with respect to instrumental records for the design of offshore and coastal structures, since they offer important advantages for the statistical char- acterization of wave climate variables, such as continuous long time records of significant wave heights, mean and peak periods, etc.然而，重新分析数据不如仪器记录准确，这使得极端数据分析从易于预测设计回报周期值下降。本文提出了一个混合的极值（MEV）模型来处理最大值，以充分利用i）i）后播或波浪重新分析，ii）仪表记录，从而降低了其预测的不确定性。所产生的混合模型始终如一地合并了两种数据集给出的信息，并且可以应用于任何极值分析分布，例如GEV或Pareto-Poisson。使用合成生成和真实数据进行了说明，后者取自西班牙北部海岸的特定地点。
基于系统评价和荟萃分析的早期糖尿病周围神经病的风险预测模型的开发和验证
结果：总共包括18个队列中T2DM的95,604例患者。年龄，吸烟，体重指数，糖尿病持续时间，血红蛋白A1C，低HDL-C，高甘油三酸酯，高血压，糖尿病性视网膜病，糖尿病性肾脏病和心血管疾病被纳入最佳模型。最高分数为52.0。验证队列的中位随访时间为4。29年。最佳切割点为17.0，灵敏度分别为0.846，特异性为0.668。根据总分数，将验证队列的患者分为低，中等，高和非常高风险的组。The risk of developing DPN was significantly increased in moderate- (RR 3.3, 95% CI 1.5–7.2, P = 0.020), high- (RR 15.5, 95% CI 7.6–31.6, P < 0.001), and very high-risk groups (RR 45.0, 95% CI 20.5–98.8, P < 0.001) compared with the low-risk group.
社论：基因组学在选择或保护牲畜种群中的应用
Genomics is one of the newest branches of biology that has progressed tremendously during the last decades. Genomics deals with the molecular structures, functions, evolution, and mapping of the genomes of any species and has signi fi cantly generated new information that has improved our understanding of the complex biology and genetic mechanisms of animal production systems. The advancement of genomics is linked with a number of key developments, which include the rapid expansion of next-generation sequencing and chip- based genotyping assays. Large-scale genomics data are now utilized more and more due to the dwindling cost of such sequencing and genotyping techniques. Livestock breeding programs, including selection and conservation efforts, have attained huge success due to affordable genomic prediction, particularly in dairy cattle. It is expected that there will be further reduction in the cost of these high-throughput genomic data generation platforms and more development of precise estimation methodologies. Multi-disciplinary involvement is going to further bene fi t the genomics community with the advancement of robust and reliable tools in the fi eld of bioinformatics and their use in livestock breeding. Keeping these developments in the area of livestock genomics in mind, the present Research topic of the Frontiers in Genetics titled “ Application of Genomics in Livestock Populations under Selection or Conservation ” was aptly selected with several major themes that highlighted the usage of genomics for conservation, current methods of genomics, application of whole-genome- and genome-wide-based techniques, and use of different bioinformatics tools and pipelines for the processing of genomic data. The resulting efforts contributed to the publication of a total 19 research papers in the current volume, comprising major focal points in the area of genomics of livestock and other species with the concerns of the present day. However, the ocean of genomics is too vast, and even this wide-array of published articles could hardly justify an ounce of that vastness! Nonetheless, genuine efforts were made to include articles in this volume on those central themes of genomics that comprise the major skills and techniques employed in various animal populations for selection and conservation issues. These include genome- wide association studies (GWAS), differential gene expression utilizing transcriptome data, and analysis of selection signatures through whole-genome sequencing and high-density genotyping datasets, which are utilized for discovering genes and genomic variants that control signi fi cant traits of importance in livestock species.
分析瞬时大脑相互作用对运动图像分类任务的贡献
这项研究的目的是分析电极之间的相互作用的贡献，即以相关性或jaccard距离测量，对运动成像范式中两种作用的分类，即左手运动和右手运动。分析是在两个分类模型中进行的，即静态（线性判别分析，LDA）模型和动态（隐藏的条件随机范围，HCRF）模型。还分析了在静态和动态模型中使用滑动窗口技术（SWT）的影响。The study proved that their combination with temporal features provides significant information to improve the classification in a two-class motor imagery task for LDA (average accuracy: 0.7192 no additional features, 0.7617 by adding correlation, 0.7606 by adding Jaccard distance; p < 0.001) and HCRF (average accuracy: 0.7370 no additional features, 0.7764 by adding相关性，通过添加Jaccard距离为0.7793；另外，我们表明，在相互作用度量或分类器本身的性质上，电极之间的相互作用显着提高了每个分类器的性能。
PARP抑制剂维持疗法的功效和安全性...
结果：这项荟萃分析涉及20个RCT，涉及7,832名参与者。The overall analysis demonstrated that maintenance therapy with PARP inhibitors led to signi fi cant improvements in PFS (HR: 0.398, 95% CI = 0.339 – 0.467, 95% PI = 0.219 – 0.724), OS (HR: 0.677, 95% CI = 0.582 – 0.788, 95% PI = 0.546 – 0.839), CFI (HR: 0.417, 95% CI = 0.368 – 0.472, 95% PI = 0.265 – 0.627), TFST (HR: 0.441, 95% CI = 0.391 – 0.498, 95% PI = 0.308 – 0.632), and TSST (HR: 0.574, 95% CI = 0.507 – 0.649,与安慰剂相比，95％PI = 0.488 - 0.674）。亚组分析进一步表明，无论同源重组状态如何，PARP抑制剂维持治疗显着改善了PFS（所有P <0.05）。但是，任何等级的风险（RR = 1.046，95％CI = 1.032 - 1.059，95％PI = 1.028 - 1.055）和≥3级茶（RR = 2.931，95％CI = 2.641 - 2.641 - 3.253，95％PI = 2.253，95％PI = 2.128 –3.792）。