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Vision是一项前瞻性，开放标签，随机，第三阶段试验，评估了先前至少使用一种ARPI和一两个类紫杉烷治疗的PSMA阳性MCRPC的患者的PLUVICTO®。随机分组（2：1），八百三十一（n = 831）患者每6周接受PLUVICTO®7.4GBQ（200 MCI），最多可容纳6剂6剂加上BSOC（n = 551）或单独使用BSOC（n = 280）。At a median follow-up of 20.9 months, PLUVICTO® plus BSoC significantly prolonged, as compared with BSoC, both alternate primary efficacy endpoints, imaging-based progression-free survival (median, 8.7 vs. 3.4 months; hazard ratio for progression or death, 0.40; 99.2% confidence interval [CI], 0.29 to 0.57; p <0.001）和总生存期（中位数为15.3 vs. 11.3个月；死亡危险比，0.62; 95％CI，0.52至0.74; p <0.001）。所有关键的次要终点（客观反应，疾病控制和有症状骨骼事件的时间）显着偏爱Pluvicto®。2
回收的PETG嵌入石墨烯，多壁...
添加剂制造（通常称为3D打印）由使用数字计算机辅助设计（CAD）的各种制造工艺编译，并通过将连续的，分层的跨层应用于构建平台，并将其处理为3D物理对象。It possesses signi cant bene ts over its more traditional formative and subtractive manufacturing counterparts, such as: on-demand manufacturing, lower (o en zero) waste, rapid prototyping capabilities, high degree of customisability, global reach as les can be modi ed and sent anywhere in the world, and the ability to create complex geometries such as nested and moving structures or overhangs.1融合细丝制造（FFF）是一种添加剂制造，由于FFF打印机的相对较低的成本及其使用的简单性，因此广泛采用了。2它涉及挤出毫米尺度的热塑性聚合物通过加热喷嘴哀叹。打印头的运动将聚合物的薄横截面绘制到上一个，并在此冷却并固体以使nal 3d对象。广泛的商业哀叹
Jason Gross
MIRI, summer 2019: Formalized type theories, and proved properties of programs that reason about themselves Google, summer 2018: Worked on integration of Fiat Cryptography with BoringSSL in Chrome Google, summer 2016: Extended Fiat Cryptography with ECC primiatives for integration with Open Titan Microsoft Research, summer 2014: Collaboratively created a language for specifying in- put/output behavior of x86 assembly programs, ver ed the input/output behavior of a number of simple programs, and improved performance of the x86proved project MIT CSAIL PLV, 20122014: Entered a signi cant amount of category theory into the au- tomated proof assistant Coq, and worked on building an interface for databases and database migration on top of category theory MIT CSAIL CoCoSci, 20092011: Designed and managed the data collection webpage for research in categorical learning and transfer learning Commack High School, 2006年2009年：对自然数量集的研究电路，赢得第四名（2009）和第三（2008年）在ISEF中获得数学奖项
Understanding Consumer Preferences for Movie Trailers from EEG using Machine Learning
Abstract —Neuromarketing aims to understand consumer be- havior using neuroscience. Brain imaging tools such as EEG have been used to better understand consumer behavior that goes beyond self-report measures which can be a more accurate measure to understand how and why consumers prefer choosing one product over another. Previous studies have shown that consumer preferences can be effectively predicted by under- standing changes in evoked responses as captured by EEG. However, understanding ordered preference of choices was not studied earlier. In this study, we try to decipher the evoked responses using EEG while participants were presented with naturalistic stimuli i.e. movie trailers. Using Machine Learning techniques to mine the patterns in EEG signals, we predicted the movie rating with more than above-chance, 72% accuracy. Our research shows that neural correlates can be an effective predictor of consumer choices and can significantly enhance our understanding of consumer behavior. Index Terms —Neuromarketing, EEG, Machine Learning, Dis- crete Wavelet Decomposition
微电网研究中心...
• Hired necessary staff and students to support the center's expansion • Finalized the designs of a state-of-the-art research and education facility which includes an expanded microgrid system which will be connected to up to 9 campus buildings • Expanded partnership network locally, nationally, and internationally • Enhanced significantly the center's modeling, prototyping, and simulation capabilities through state- of-the-art advanced prototyping testbeds支持能源启动，研究和创新•创建了一个在线存储库，以围绕分布的能源资源和网格技术创建一个在线存储库，这将明尼苏达州置于创新的领先地位，并为人工智能和机器学习创新打开了大门，以实现人工智能和机器学习创新•通过谈判，社交媒体的范围，社会媒体的范围，社交媒体，社交媒体，社会媒体，社会媒体，社会媒体的范围，•杠杆资金以在微电网控制，电动汽车，网络安全和插件通讯领域与美国陆军工程兵团获得2年的1100万美元研究赠款。此外，该联邦资金支持该中心的研究基础设施，并将完成微电网扩展
一种新型超分子Zn（II）-Metallogel -RSC Publishing
胆固醇，27岁和酰胺28在凝胶的化学中是一般的，利用LMWGS实现了必要的和有效的合成，仍然很不错。与超分子凝胶化过程的演示一起，凝胶研究29中的当前方向是金属离子以及LMWGS以及用于形成多功能超分子抗凝胶的LMWG。低分子量的多种金属离子和有机成分的组合结合在一起，以产生具有独特的自我聚集机制和非共价特征的母凝度，从而导致在科学和技术领域发展更具吸引力和出色的特性。Supramolecular metallogels have signi cant applications in a wide range elds of materials science, including the food industry, cosmetics, electron emission, photophysics, logic gates, drug delivery, cell culturing, biomineralization, medical diagnostics, tissue engineering, lithography, optical activity, energy storage, charge transportation, catalysis, conductivity, actuators, magnetic materials, redox responsive- ness,化学传感器，电化学和光电设备，纳米科学和纳米电子学等30 - 49
COVID-19期间能量转化的挑战和机遇
摘要：由于建筑物的高能源需求，该建筑物在2020年占全球份额的36％，因此它们是能源耐能力研究和法规的核心目标之一。因此，再加上分散电网的复杂性日益复杂和可再生能源渗透，智能建筑物的创建变得越来越紧迫。Data-driven building energy management systems (BEMS) based on deep reinforcement learning (DRL) have attracted significant research interest, particularly in recent years, primarily owing to their ability to overcome many of the challenges faced by conventional control methods related to real-time building modelling, multi-objective optimization, and the generalization of BEMS for efficient wide deployment.进行了基于PRISMA的470篇大型数据库的系统评估，以回顾基于DRL的BEM的最新进展，用于不同的建筑类型，其研究方向和知识差距。确定了五种建筑物类型：住宅，教育，数据中心和其他商业建筑。他们的比较分析是根据由BEM，可再生能源整合，DR和独特的系统目标控制的设备和系统的类型进行的，例如成本和舒适性。此外，值得考虑的是，最近大约只有11％的研究考虑了实际系统实施。
单独或在转移性或晚期肾细胞癌治疗中的PD-1/PD-L1抑制剂的功效和安全性：网络荟萃分析
Results: Based on eleven studies, the effectiveness of the experimental group was found to be signi fi cantly better than the control in terms of overall survival (OS) [R=0.74, 95%CI: 0.69~0.80, P <0.00001], progression-free survival (PFS) [HR=0.68, 95%CI: 0.57~0.81, P <0.0001], objective response rate （ORR）[RR = 1.71，95％CI：1.39〜2.12，p <0.00001]，完全响应率（CR）[RR = 2.99 95％CI：2.34〜3.83，p <0.0001]，部分响应率（PR）[RR = 1.56，95％CI：1.20 〜2.011，PRR） [RR = 1.13，95％CI：1.06〜1.20，p <0.0001]。在整体不良反应（AES）[RR = 1.01，95％CI：0.98〜1.04，p = 0.598]中，实验组和对照组之间没有观察到未观察到的统计学意义。 [RR = 0.98，95％CI：0.81〜1.18，p = 0.817]。关于亚组分析，吞咽困难，皮疹，甲状腺功能减退症，亚腹和瘙痒的发生率显着高于对照组。与对照组相比，实验组的腹泻，恶心，消化不良和疲劳的发生率在统计学上没有显着。
甘氨酸最大酰基 - 酰基 - 酰基载体蛋白硫酯酶B基因...
与饱和脂肪酸合成的脂肪酰基 - 酰基载体蛋白硫酯酶B（FATB）基因在脂肪酸含量和储存脂质的组成中起着重要作用。然而，FATB在大豆中的作用（甘氨酸最大）的特征很差。本文提出了10个假设FATB成员的初步生物信息学和分子生物学研究。结果表明，GMFATB1B，GMFATB2A和GMFATB2B包含许多参与防御和压力反应以及分生组织组织表达的响应元素。此外，GMFATB1A和GMFATB1B的编码序列比其他基因明显更长。它们的表达在生长过程中在大豆植物的不同器官中有所不同，GMFATB2A和GMFATB2B显示出较高的相对表达。此外，亚细胞定位分析表明，它们主要存在于叶绿体中。Overexpression of GmFATB1A , GmFATB1B , GmFATB2A and GmFATB2B in transgenic Arabidopsis thaliana plants increased the seed oil content by 10.3%, 12.5%, 7.5% and 8.4%, respectively, compared to that in the wild-type and led to signi fi cant increases in palmitic and stearic acid content.因此，这项研究增强了我们对大豆中FATB家族的理解，并为随后改善大豆质量提供了理论基础。
回顾与儿童肠道微生物组失调相关的神经发育障碍
摘要：人类肠道微生物组的形成在子宫内启动，其成熟是在生命的第2-3年期间构成的。许多因素改变了肠道微生物及其功能的组成，包括分娩方式，母乳喂养的早期发作，暴露于抗生物剂和化学物质以及孕产妇应力等。肠道微生物组 - 脑轴是指允许肠道微生物组和大脑之间双向通信的生物网络的互连，涉及神经，内分泌和免疫系统。证明肠道微生物组及其代谢副产品的证据积极地与早期大脑发育的调节有关。在此阶段的任何干扰可能会对脑功能产生不利影响，从而导致各种神经发育障碍（NDDS）。In the present study, we re- viewed recent evidence regarding the impact of the gut microbiome on early brain development, alongside its correlation with significant NDDs, such as autism spectrum disorder, attention-defi- cit/hyperactivity disorder, Tourette syndrome, cerebral palsy, fetal alcohol spectrum disorders, and genetic NDDs (Rett, Down, Angelman, and Turner syndromes).了解NDD中肠道微生物组的变化可能会为他们的治疗提供新的机会。