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Prof. Opie's major interest has been in the field of cardiology, in relation to the application of metabolic therapy to heart disease, starting with three early Nature articles that led to a major recent clinical study in conjunction with Tufts University, Boston, and published in the Journal of the American Heart Association , on the benefits of glucose-insulin- potassium (GIK) infusions given in the ambulance to patients with very early heart attacks.在Hatter Institute（1997-2010）（1997-2010）进行的主要小说工作中，受Sandrine Lecour教授的启发，发现了生存因子增强因子增强（安全）路径，从而赋予了分子和代谢有氧运动保护，从而使心脏病发作受害者受益。他的其他许多研究都涉及急性心力衰竭，心血管药物疗法和高血压。
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