• Provided a written informed consent form • Females in the study were not pregnant and could not become pregnant • Males in the study agreed to use birth control and refrain from donating sperm • People with normal brain function were 65 to 90 years old and had at least one close relative with Alzheimer's disease • People with Alzheimer's disease were 50 to 90 years old and met the brain test scores for the disease • Other tests were also used for staging people into具有不同脑功能水平的组,包括临床痴呆评级,小精神状态检查,β-淀粉样蛋白宠物成像和大脑MRI成像,如果遇到以下任何一个条件,人们将无法参加研究:
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