KEYNOTE ADDRESS: NIGEL JAMIESON Professor of Surgery and Consultant HPB Surgeon, Group Leader of Jamieson Spatial Laboratory, Cancer Research UK Clinician Scientist, School of Cancer Sciences, University of Glasgow Insights from molecular mapping of gastrointestinal cancer across space and time Studying clinical cohorts using spatial transcriptomics technologies offers the potential to impact our understanding of patient's tumours.我们的中心假设是单细胞空间表征将揭示治疗脆弱性在研究免疫细胞群体而没有空间上下文时看不到。我们旨在揭示癌细胞之间的空间相互作用,而微环境作为肿瘤进展的决定因素,包括胰腺癌和结直肠癌在内的各种胃肠癌。我们已经在主要和转移性环境中使用区域和单细胞转录组学策略来表征大量的人类GI癌,以更好地了解治疗和疾病进展的影响。
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