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Title and abstract 1 (a) Indicate the study's design with a commonly used term in the title or the abstract (b) Provide in the abstract an informative and balanced summary of what was done and what was found Introduction Background/rationale 2 Explain the scientific background and rationale for the investigation being reported Objectives 3 State specific objectives, including any prespecified hypotheses Methods Study design 4 Present key elements of study design early in the paper Setting 5 Describe the setting, locations, and相关日期，包括招聘，接触，随访和数据收集参与者的期限6（a）同类研究 - 确定资格标准以及参与者选择的来源和方法。描述随访的方法（b）队列研究 - 进行匹配的研究，给出匹配的标准以及暴露和未暴露的N/A
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