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1珀德研究小组，卫生技术与服务研究中心（CINTESIS），RUA PL医生到Cido da Costa，4200-450 Porto，Porto，葡萄牙； lara.marques2010@hotmail.com（l.m.）; B.C.211297@gmail.com（B.C.）; mariana.m.pereira2097@gmail.com（M.P.）; abigailsilva@outlook.pt（A.S。）; jmdmsantas@hotmail.com（J.S.）; leonorpessanha@gmail.com（l.s.）; iumsmed@gmail.com (i.s.)2 Cintes@Rise, Faculty of Medicine, University of Porto, Professor Hern  Ni Monteiro, 4200-319 Porto, Portugal 3 Department of Community Medicine, Health Information and Decision Porto, Portugal 4 ICBAS-SCHOOL OF MEDICINE AND BIOMEDICAL SCIENCES, University of Porto, Rua de Jorge Viterbo Ferreira, 4050-313 Porto, Portugal 5 Department of Biomedicine, Faculty of Medicine, University of Doctor PL Costa, 4200-450 Porto, Portugal 6 Coimbra Institute for Biomedical for Biomedical Polo 3 Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; paulo.r.magalhaes1@gmail.com 7药物学和系统药理学中心，佛罗里达大学药学系，药学系，佛罗里达州奥兰多市465号桑格路6550号，美国佛罗里达州32827-7400； sschmidt@cop.ufl.edu *通信：nunovale@med.up.pt;电话。： +351-220426537
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