• Low Hb usually >90g/l, low reticulocyte count • Unable to utilise iron • Normal or low MCV • High ferritin (acute phase/not utilised) • High CRP • May have low EPO, but often normal, few respond • Mediated by TNF, IFN, hepcidin • If iron deficient %sat low, ferritin low-normal • Trial of oral iron often indicated - will need investigation •慢性疾病的贫血可能会对铁输液反应