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Effective Option for Patients with Type 2 Diabetes Marlborough, MA – January 8, 2024 – TheracosBio today announced the publication of a meta-analysis that confirms the cardiovascular safety profile of BRENZAVVY® (bexagliflozin), an FDA-approved oral sodium-glucose cotransporter 2 (SGLT2) inhibitor indicated as an adjunct to diet和运动以改善2型糖尿病成年人的血糖控制。这项研究发表在糖尿病，肥胖和代谢上，详细介绍了对9阶段2和3研究的预先指定分析的结果，用于获得Brenzavvy的FDA批准。这项研究有能力确定FDA指定的安全性幅度，并且重大不良心血管事件（MACE）的点估计值大大低于用于计划目的的1.00的值，因此批准前计划还满足了批准后安全性的要求。尽管荟萃分析没有将Brenzavvy与班级其他药物进行比较，但心血管的发现与其他SGLT抑制剂试验报告的发现是一致的。“These data clearly demonstrate that long-term use of BRENZAVVY, even in patients at high risk for future cardiovascular disease, does not increase CV risk and should give physicians confidence in the overall safety profile of BRENZAVVY,” said Mason W. Freeman, MD, Professor of Medicine at Harvard Medical School and Director of the Translational Medicine Group at Massachusetts General Hospital, who was one of the study's authors.“我们小组在MGH负责的整个Brenzavvy计划中重大不良心血管事件的危险比的点估计值类似于
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