Katarzyna Kozak:发言人Honoraria - BMS,MSD,Novartis,Pierre Fabre,Sanofi;顾问委员会-BMS,MSD; Pawel Sobczuk:发言人Honoraria - BMS,Swixx Biopharma,Gilead;旅行补助金 - BMS,MSD,诺华,皮埃尔·法布尔;顾问委员会 - Sandoz;股东 - Celon Pharma;董事会成员 - 波兰临床肿瘤学会; Tomaszświtaj:发言人Honoraria - BMS,MSD,Novartis,Pierre Fabre,Sanofi;旅行补助金 - BMS,MSD,诺华,皮埃尔·法布尔; PawełTeterycz:发言人Honoraria - BMS,MSD,Novartis,Pierre Fabre;旅行补助金 - BMS,MSD,诺华,皮埃尔·法布尔; Aneta Borkowska和Sylwiakopeć宣布没有利益冲突; Piotr Rutkowski:发言人Honoraria - BMS,Merck,MSD,Novartis,Pierre Fabre,Sanofi;顾问委员会 - 蓝图药物,BMS,默克,MSD,Philogen,Pierre Fabre,Sanofi;研究资金 - BMS,辉瑞。
• SEER 疾病范围 1988:代码和编码说明(第 3 版,1998 年) (https://seer.cancer.gov/archive/manuals/EOD10Dig.3rd.pdf) • SEER 总结分期手册-2000:代码和编码说明 (https://seer.cancer.gov/tools/ssm/ssm2000/) • 协作分期数据收集系统,版本 02.05:https://cancerstaging.org/cstage/Pages/default.aspx • Springer International Publishing 出版的 AJCC 癌症分期手册第 8 版 (2017) 第 40 章头颈部软组织肉瘤。经伊利诺伊州芝加哥美国外科医师学会许可使用。 • Springer International Publishing 出版的 AJCC 癌症分期手册第八版 (2017) 中的第 41 章“躯干和四肢软组织肉瘤”。经伊利诺伊州芝加哥美国外科医师学会许可使用。 • Springer 出版的 AJCC 癌症分期手册第八版 (2017) 中的第 42 章“腹部和胸腔内脏器官的软组织肉瘤”
EpiFix or Grafix ® (GrafixPL, GrafixPRIME, and GrafixPL PRIME) (Non-Injectable) EpiFix or Grafix is proven and medically necessary for treating a diabetic foot ulcer when all of the following criteria are met: • Adequate circulation to the affected extremity as indicated by one or more of the following: o Pedal pulses palpable or pulses confirmed with doppler examination o Ankle-brachial index (ABI) between 0.7 and 1.2 • Glycated hemoglobin test (HgA1c) < 12% (within the last 90 days) • Ulcer has failed to demonstrate adequate healing with at least 4 weeks of standard wound care which includes all of the following: o Application of dressings to maintain a moist wound environment o Debridement of necrotic tissue if present o Offloading • No known contraindications which may include but不限于以下几点:o受影响的脚部的活性型炭畸形或对溃疡的慢性感染的主要结构异常o已知或怀疑正在治疗的溃疡的恶性肿瘤不会扩展到肌腱,肌肉,肌肉,胶囊或骨骼或骨
人工智能 (AI) 和机器学习的最新进展为肌肉骨骼放射学提供了大量机会,有可能提高诊断准确性、工作流程效率和预测模型。AI 工具能够协助放射科医生完成图像分割、病变检测等多项任务。在骨和软组织肿瘤成像方面,放射组学和深度学习有望实现恶性肿瘤分层、分级、预后和治疗计划。然而,在临床转化之前,需要解决标准化、数据集成和患者数据的伦理问题等挑战。在肌肉骨骼肿瘤学领域,由于发病率有限,AI 在稳健算法开发方面也面临着障碍。虽然许多计划旨在开发多任务 AI 系统,但多学科合作对于将 AI 成功融入临床实践至关重要。需要采取稳健的方法来应对挑战并体现道德实践,以充分发挥 AI 在提高诊断准确性和推进患者护理方面的潜力。
https://www.cancer.govseves-cong-clog/ewat-s.10.10.10.10.10.105/nejme215 https://www.nejm.m.org/doii/iull/10.10.10.10.1056/nejmoa2222212083
我们已经从肽二氢硫醇融合的2-吡啶酮支架中开发了GMPCIDES,该二吡咯酮融合了抗微生物活性,该酮具有抗微生物活性。在这里,我们使用皮肤和软组织感染(SSTI)和生物膜形成模型来检查GMPCIDES的治疗功效。筛选我们的化合物文库中的最小抑制性(MIC)和最小杀菌(MBC)浓度鉴定为对pyogenes的GMPCIDE PS757的浓度高度活跃。使用PS757对化脓性链球菌生物膜进行处理,揭示了通过防止初始生物膜发展,停止生物膜成熟并消除成熟生物膜的生物膜形成的所有阶段。在孢子链球菌SSTI的鼠模型中,皮下递送PS757导致组织损伤水平降低,细菌负担降低以及伤口愈合的加速速率,这与关键的病毒率因子的下调有关,包括M蛋白和SPEB蛋白质和SPEB固醇蛋白酶。这些数据表明,GMPCIDES对治疗化脓性链球菌感染显示出巨大的希望。
提高对癌症治疗和不育风险的性腺毒性的认识对于咨询年轻癌症患者至关重要。虽然许多国家可以提供生育能力,但有关促性毒性的数据有限,尤其是对于软组织癌的建议。这篇评论是由Fordiprotekt(www.fertiprotekt.com)组织的Forditox项目(www.fertitox .com)的一部分,旨在解决此知识差距以改善生育能力保存指南。我们对软组织肉瘤(STS)癌症治疗中的性腺毒性进行了系统的文献搜索。仅考虑没有转移或复发性疾病的患者。 “可疑的不育症”是根据低卵巢储备参数,低抑制素B水平,高促性腺激素浓度,促性腺功能障碍,闭经症,低亲瘤性,Azoospermia或寡植物植物植物的寡植物的定义定义的。 使用纽卡斯尔 - 渥太华量表对学习质量进行了评估。 搜索产生了3309个摘要,其中有138个进行全文分析。 包括对ST的八项研究。 在28位女性中有20例(71.4%,范围0-100%)和63名男性中的38例(60.3%,范围34.8 - 100%)观察到了怀疑的不育症。 八项研究中有六项在NOS上获得了高质量的分数,而两项获得了公平分数。 我们的数据表明,在前和后体STS幸存者中,化学疗法不孕的高风险。 这强调了在为这些患者提供咨询时考虑生育措施的重要性。仅考虑没有转移或复发性疾病的患者。“可疑的不育症”是根据低卵巢储备参数,低抑制素B水平,高促性腺激素浓度,促性腺功能障碍,闭经症,低亲瘤性,Azoospermia或寡植物植物植物的寡植物的定义定义的。使用纽卡斯尔 - 渥太华量表对学习质量进行了评估。搜索产生了3309个摘要,其中有138个进行全文分析。包括对ST的八项研究。在28位女性中有20例(71.4%,范围0-100%)和63名男性中的38例(60.3%,范围34.8 - 100%)观察到了怀疑的不育症。八项研究中有六项在NOS上获得了高质量的分数,而两项获得了公平分数。我们的数据表明,在前和后体STS幸存者中,化学疗法不孕的高风险。这强调了在为这些患者提供咨询时考虑生育措施的重要性。
目录1。Introduction ................................................................................................................................ 7 2.上下文和理性.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................Material and method ................................................................................................................ 10 3.1.研究类型和目标........................................................................................................................................................................................................................................................................................................... 10 3.2。Study population ....................................................................................................................... 10 3.3.研究人群的选择阶段和不同目标的子种群。113.4。Population distribution criteria ................................................................................................. 12 3.4.1.Classification of hospitals .......................................................................................................... 12 3.4.2.根据专业,方法和类型的手术分类........................................... 12 3.4.3。Geographic distribution ............................................................................................................. 12 3.5.Statistical Analyses .................................................................................................................... 13 4.目标1:2021年和2022年在法国机器人辅助手术的全国概述.... 14 4.1。Method ...................................................................................................................................... 14 4.2.Results ....................................................................................................................................... 15 4.3.Conclusions ................................................................................................................................ 18 5.目标2:评估2022年法国的不同手术方法及其区域差异,特别是对于机器人辅助手术的率。Method ...................................................................................................................................... 19 5.2.Objective 2 population .............................................................................................................. 20 5.3.Results ....................................................................................................................................... 21 5.3.1.Global vision on all specialties ................................................................................................... 21 5.3.2.Urology ...................................................................................................................................... 24 5.3.3.General and digestive - non bariatric ........................................................................................ 26 5.3.4.根据专业的机器人活动在区域中的分布。一般和消化 - 减肥剂................................................................................................................................................................................................................................................................................... 28 5.3.5。Gynecology - hysterectomies .................................................................................................... 30 5.3.6.Gynecology - sacrocolpopexies ................................................................................................. 32 5.3.7.Thoracic ..................................................................................................................................... 34 5.3.8.Conclusions ................................................................................................................................ 38 6.Objective 3: ............................................................................................................................... 40 Estimation of the real-life impact of RAS for soft tissue compared to other surgical approaches in terms of length of stay, rate of ICU stay, and 30- and 90-days revision rates ..................................... 40 Statistical comparison between « laparo/thoracoscopic » approach and « robotic - high volume hospitals » approach ............................................................................................................................ 40 6.1.Method ...................................................................................................................................... 40 6.2.Results for each type of surgeries ............................................................................................. 43 6.2.1.Urology ...................................................................................................................................... 43 6.2.2.一般和消化 - 非减肥剂................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 47 6.2.3。一般和消化 - 减肥剂......................................................................................................................................................................................................... 51 6.2.4。Gynecology - hysterectomies .................................................................................................... 53 6.2.5.Gynecology - sacrocolpopexies ................................................................................................. 55 6.2.6.Thoracic ..................................................................................................................................... 57 6.3.Conclusions ................................................................................................................................ 59 7.General discussion .................................................................................................................... 62 7.1.Elements for which our study provides answers ....................................................................... 62 7.2.上下文紧急情况....................................................................................................................................................................................................................................................................................................................................... 67 7.3。Switch to Surgery 4.0 ................................................................................................................. 68 7.4.Conditions for completing Surgery 3.0 ...................................................................................... 69 7.4.1.Yellow Item: relevance of care and health democracy .............................................................. 69 7.4.2.Green Item: standardization of practices and surgical procedures ........................................... 70
•2024年4月3日进行了全面而系统的文献搜索。• The search was done on commercial medical literature databases, including BIOSIS Previews (1969 to 2008), Embase (1974 to 2024 Week 13), Medline and Epub Ahead of Print, Medline In-Process, In-Data-Review & Other Non-Indexed Citations, Medline Daily and Medline (1946 to April 02, 2024), Joanna Briggs Institute Evidence Based Practice Database (Current to March 27, 2024年),Cochrane临床答案(2024年3月),可通过OVID平台获得。•在此搜索中采用了关键字的组合。这些关键字包括: