第二行处理选项 *在以下情况下a)至e): (tofacitinib +mtx,upadacitinib +/- mtx)或apremilast +/- mtx或其他口服dmard或IL- 23抑制剂(Guselkumab,risankizumab,risankizumab)+/- mtx(N.B.使用利济氏菌的其他标准 - 中度至重度的牛皮癣(至少3%的身体表面积受斑块牛皮癣影响和牛皮癣面积和严重程度指数[PASI]得分大于10)b) +/- MTX,或考虑“ A”场景中列出的治疗方案。c) If previously treated with TNF Inhibitor+/- MTX AND inadequate response after 12 weeks: Consider the treatment options stated in scenario ‘ b ' d) If previous treatment was not a TNF Inhibitor +/- MTX, AND inadequate response after 12 weeks: Consider switching to a TNF inhibitor +/- MTX or the alternate treatment options stated in scenario ‘a ' e) If TNF inhibitor is contra-indicated: Consider IL-17A inhibitor (Secukinumab *** , Ixekizumab ** , Bimekizumab) +/- MTX, or IL-12/23 inhibitor (Ustekinumab) +/- MTX or JAK Inhibitor ∞ (Tofacitinib + MTX, or , Upadacitinib +/- MTX) Apremilast (+/- MTX或另一个口服DMARD)或IL-23抑制剂(Guselkumab,risankizumab)+/- MTX(请参见上文 - 其他标准适用于Risankizumab)
主要关键词