摘要。DNA从2个伟大的猿骨架,锅troglodytes(Ptr)和Pongo Pygmaeus(PPY)中回收,属于19世纪的动物学系列。The skeletons presented morphological alterations possibly associated with β-thalassemia: Ptr had deformation of the calvaria and oro-maxillo-facial bones with porotic hyperostosis and extended osteoporotic lesions of the skeleton, while Ppy showed a general marked widening of the calvarial diploe but moderate osteoporotic signs on the post-cranial skeleton.,我们筛选了PTR和PPY,以在β-珠蛋白基因(外显子1、2和3)中进行突变,因为我们怀疑地中海贫血。PTRβ-球蛋白序列显示出与人类的相似程度最高(99.8%),而PPY的相似性略有不同(98.2%)。结果与其β-珠蛋白基因序列之间的系统发育关系一致。我们没有在PTR和PPY的β-珠蛋白基因中发现任何突变。