治疗方法,现有疗法主要依赖于运动和饮食控制。因此,迫切需要对该疾病的新药或治疗靶标。葡萄糖共转运蛋白2(SGLT2)是葡萄糖共转运蛋白家族之一。它主要存在于肾脏的肾近端小管中,并介导葡萄糖的重吸收。The represen- tative drug of SGLT2 inhibitors (SGLT2i) is dapagliflozin, a new class of hypoglycaemic drug, which has an ac- tion mechanism that reduces blood glucose by inhibiting the reabsorption of glucose by the proximal convoluted tubules of the kidney, thus allowing excess glucose to be excreted from urine.研究表明,SGLT2I不仅降低了血糖,而且对肝功能具有保护作用[6]。但是,具体机制尚未确定。NAFLD的发病机理很复杂,但主要集中于胰岛素抵抗和炎症,血液中肝酶的变化是确定