Dry mouth 0 5 (41.7) 5 (29.4) 3 (33.3) 2 (20) 0 2 (66.7) 3 (60) 3 (50) 23 (31.5) Pruritus 0 1 (8.3) 3 (17.6) 1 (11.1) 3 (30) 1 (11.1) 1 (33.3) 1 (20) 4 (66.7) 15 (20.5) Alopecia 0 2 (16.7) 1 (5.9)2(22.2)1(10)1(11.1)0 4(80)3(50)14(19.2)腹泻1(50)3(50)3(25)1(5.9)0 2(20)3(33.3)0 1(20)2(20)2(33.3)2(33.3)13(33.3)13(33.3)13(17.8)实验室不良事件(17.8)实验室不良事件(≥15%)AST 0 4(3.3)3(3.3)3(3. 3. 3. 3(3)(3. 3. 3(3)(3. 3. 3. 3. 3(3) 2(22.2)1(33.3)1(20)1(16.7)19(26)降低血小板计数C 0 1(8.3)1(5.9)4(44.4)1(10)1(22.2)2(22.2)1(33.3)2(40)2(40)4(66.7)16(66.7)16(21.9)Alt (40)1(16.7)15(20.5)肌钙蛋白增加D 0 2(16.7)1(5.9)2(22.2)1(10)1(33.3)0 3(60)0 12(16.4) (22.2)0 0 0 0 0 0 2(33.3)5(6.8)任何导致剂量中断1(50)3(25)6(35.3)5(55.6)0 3(33.3)0 5(33.3)0 5(100)4(66.7)27(66.7)27(37)27(37)27(37)剂量限制剂量的毒性毒性的毒性毒性的毒性0 1(5.9) (20)0 1(1.4)血小板计数减小0 0 0 0 0 0 0 0 0 0 1(16.7)1(1.4)皮疹E 0 0 0 0 0 0 0 0 0 0 0 0 1(16.7)1(1.4)