中弹性动脉和大型弹性动脉的自身免疫性血管炎会引起失明,中风,主动脉弓综合征和主动脉瘤。这种疾病通常是对免疫抑制疗法的难治性,并且在闷烧的主动脉炎中进展了数十年。如何保持血管壁中的颗粒浸润以及如何补充组织浸润的T细胞和巨噬细胞。血管动脉中免疫细胞种群的单细胞和整个组织转录组研究鉴定出具有干细胞样特征的CD4 + T细胞群。CD4 + T cells supplying the tissue-infiltrating and tissue-damaging effector T cells survived in tertiary lymphoid structures around adventitial vasa vasora, expressed the transcription factor T cell factor 1 (TCF1), had high proliferative potential, and gave rise to two effector populations, Eomesodermin (EOMES) + cytotoxic T cells and B-cell lymphoma 6 (BCl6) + T卵泡辅助辅助细胞。TCF1 HI CD4 + T细胞在连续移植实验中表达白介素7受体(IL-7R)持续的血管炎。因此,TCF1 HI CD4 + T细胞充当疾病干细胞
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