Well-Perfused Tissues: Brain, Heart, Kidney, Splanchnic organs >>> Skeletal Muscles Poorly-Perfused Tissues: Fat, Bone and other viscera Example: IV bolus of propofol High blood flow & high lipophilicity Rapid distribution into CNS Anesthesia Hypnosis Subsequent slower distribution to skeletal muscle & adipose tissue 血浆浓度。降低了从中枢神经系统降低梯度意识恢复2.毛细管渗透性(由毛细管结构(即由内皮细胞之间的缝隙连接和药物的化学性质暴露于缝隙的地下膜的一部分)
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