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au：PleaseconfirnheadinglevelsarerepressedCorceconcely：系统性自身免疫性疾病与异常反应性的先天性和适应性免疫反应有关，导致组织损害并增加发病率和死亡率。自身免疫与免疫细胞的代谢功能的改变有关（免疫代谢），更具体地说是与线粒体功能障碍的变化。Much has been written about immunometabolism in autoimmunity in general, so this Essay focuses on recent research into the role of mitochondrial dysfunction in the dysregulation of innate and adaptive immunity that is characteristic of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).增强对自身免疫性线粒体失调的理解将有助于加快这些挑战性疾病的免疫调节治疗的发展。
自身免疫性疾病发病机理中免疫系统的代谢改变
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