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Highly accurate long-read single-molecule sequencing has revolutionized the comprehensive assembly of phased genetic architectures (Wenger et al.2019; Vollger等。2020; Nurk等。2022）。In addition, long-read single-molecule sequencing has permitted the direct identification of modified DNA bases such as m6A and 5-methylcytosine (5mC) (Marks et al.2012;克拉克等。2012; Murray等。2012; Loman等。2015; [CSL样式错误：没有印刷表格的参考。]）启用单分子染色质纤维测序（Stergachis等人2020; Lee等。2020; Abdulhay等。2020; Shipony等。2020）。Specifically, single-molecule chromatin fiber sequencing leverages non-specific methyltransferases to selectively stencil chromatin protein occupancy patterns directly onto their underlying DNA molecules in the form of modified bases.修饰碱基。For example, during single-molecule, real-time (SMRT) sequencing, the identity of each base is determined based on the fluorophore-labeled
用RVSV二价疫苗进行口服免疫，包括ADCC在内的保护性免疫反应，包括SARS-COV-2和流感A病毒
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