CYP3A4 interactions In vivo studies have shown that oral administration of ketoconazole or itraconazole (known inhibitors of CYP3A4 activity in the liver and in the intestinal mucosa, also see Interactions with other medicines and other forms of interaction ) may cause a several-fold increase of the systemic exposure to budesonide and consequently lead to systemic adverse reactions, such as Cushing's Syndrome.如果指示用酮康唑或伊曲康唑以及布德索尼治疗,如果发生全身性糖皮质激素的典型副作用,应考虑降低布德索尼剂剂量。
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