SARS-COV-2 OMICRON XBB子变量有效地逃避了先前感染或疫苗接种的免疫力,需要适应疫苗。在这里,我们分析了适应疫苗的免疫原性BNT162B2 Omicron XBB.1.5,该疫苗目前用于增强疫苗。增强疫苗接种显着增加了抗尖峰IgG,并伴随着识别wuhan和Omicron XBB.1.5 Spike变体的交叉反应性记忆B细胞的扩展。几何平均中和滴度相对于XBB.1.5,XBB.1.16和XBB.2.3,以及针对Eg.5.5.1和BA.2.86的交叉反应响应相对于前增强前滴度显着增加。最后,武汉和XBB的数量1.5峰值反应性IFN-γ产生的T细胞在促进疫苗接种后显着增加。In summary, BNT162b2 Omicron XBB.1.5 vaccination resulted in potent neutralizing antibody responses against Omicron XBB variants, including the recent Omicron variants EG.5.1 (Eris) and BA.2.86 (Pirola), as well as XBB.1.5 reactive T cell responses, suggesting that booster vaccination will augment protection against these emerging变体。
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