帕特里克·T·加西亚（Patrick T.Box 7062 Johnston, IA 50131 RSR number 24-172-01rsr RE: Regulatory Status Review of corn developed using genetic engineering for expression of a resistance (R) protein that recognizes effector protein secreted by Setosphaeria turcica and signals a hypersensitive response that destroys infected tissue through programmed cell death, expression of a wall-associated kinase protein that triggers检测到setosphaeria turcica后的下游免疫反应，非典型模式识别受体（PRR）蛋白的表达，只有一个富含亮氨酸的重复区域，可触发下游免疫反应，在检测到L型晶状体酶蛋白蛋白蛋白蛋白蛋白蛋白蛋白蛋白蛋白蛋白质酶的表达后，该反应是trake kin酶蛋白的表达 zeae-maydis , expression of a protein that recognizes effector protein secreted by Colletotrichum graminicola and signals a hypersensitive response that destroys infected tissue through programmed cell death, and expression of a protein that recognizes effector protein secreted by Puccinia polysora and signals a hypersensitive response that destroys infected tissue through programmed cell death Dear Mr. Garcia: Thank you for your letter dated 2024年8月16日，要求对使用基因工程（改良玉米）开发的玉米进行监管状态审查（RSR）。In your letter, you described that the corn was modified to impart resistance to northern corn leaf blight, resistance to gray leaf spot, resistance to anthracnose stalk rot, and resistance to southern corn rust via expression of a resistance (R) protein that recognizes effector protein secreted by Setosphaeria turcica and signals a hypersensitive response that destroys infected tissue through programmed cell death, expression of a wall-associated kinase protein that triggers downstream immune responses after detecting Setosphaeria turcica , expression of an atypical pattern recognition receptor (PRR) protein, with only a leucine rich repeat region that triggers downstream immune responses after detecting Cercospora zeae-maydis , expression of an L-type lectin receptor kinase protein that triggers downstream immune responses after detecting Cercospora zeae- maydis , expression of a protein that recognizes effector protein secreted by Colletotrichum graminicola and signals a hypersensitive response that destroys infected tissue through programmed cell death, and expression of a protein that recognizes effector protein secreted by Puccinia polysora and signals a hypersensitive response that destroys infected tissue through programmed cell death.