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a b s t r a c t最佳脐带血（CB）单位选择对于最大程度地提高了CB移植后成功植入和生存的可能性至关重要。但是，单位选择可能很复杂，因为必须考虑多个特征，包括单位细胞剂量，供体 - 供体的人白细胞抗原（HLA）匹配和单位质量。本评论提供了基于证据和基于经验的CB单位选择的综合准则。Topics addressed include the use of both the TNC and the CD34 + cell dose, as well as the CD34 + cell to TNC content ratio to evaluate unit progenitor cell content and engraftment potential, the acceptable TNC and CD34 + cell dose criteria that de fi ne an adequate single-unit graft, and the indication and acceptable cell dose criteria for double-unit grafts.The acceptable criteria for 6-loci (HLA-A, -B antigen, -DRB1 allele) and 8-allele (HLA-A, -B, -C, -DRB1) donor-recipient HLA match, the evaluation of patients with donor-speci fi c HLA antibodies, and the multiple deter- minants of unit quality are also reviewed in detail.最后，概述了CB搜索的实用分步指南和指导最终移植选择的原则。©2020美国移植和细胞疗法学会。由Elsevier Inc.出版
脐带血单位选择指南
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