•Astellas与Elpiscience的研究合作和许可协议与新颖的双摩托巨噬细胞企业,包括预期和期权费用高达3,700万美元,并可能在未来的开发,监管和商业里程碑中超过17亿美元。•加拉帕戈斯(Galapagos)关于将其Jyseleca®业务转移到Alfasigma的预期转让,包括欧洲和英国营销授权,Jyseleca®的商业,医疗和开发活动,在14个欧洲国家 /地区约有400 FTE。•Astellas与Cullgen的战略合作和期权协议中,以推进创新的目标蛋白质降解器,如果Astellas行使所有计划的所有许可证和所有里程碑,则薪酬可能超过19亿美元。•L'Oréal与首次亮相的战略合作伙伴关系,以使用首次专有的无细胞和生物技术模型开发各种新颖的成分,美容和个人护理产品。•L'Oréal与L'Oréal合作,将稳定技术的稳定技术纳入L'Oréal的智能化妆涂抹器,适合手动和手臂移动性有限的用户。•默克·夏普(Merck Sharp&Dohme)与Peptidream Inc.合作和许可协议,以发现和开发新型肽药物候选者,包括有可能获得21亿美元的监管,开发和商业里程碑。•加拉帕戈斯(Galapagos)以预先获得1.25亿欧元的CellPoint(包括其CAR-T治疗的分散式护理生产模型),其里程碑付款高达1亿欧元。• Vividion Therapeutics (a wholly owned and independently operated subsidiary of Bayer AG) in its strategic collaboration with Tavros Therapeutics to discover and enhance targeted oncology programs, including an upfront of USD 17.5 million, up to USD 430.5 million in milestone payments for four initial programs, and, if Vividion exercises its opt- in for up to five more targets, up to USD 482额外付款。•Bristol-Myers Squibb与Synthex的研究合作,发现和开发有针对性的蛋白质降解治疗疗法,在此过程中,Synthex将获得前期的前期,并有资格获得高达5.5亿美元的基于绩效的里程碑支付,以及全球网络的特许权使用费。• Astellas in its worldwide strategic collaboration with Sutro Biopharma to advance novel immunostimulatory antibody-drug conjugates (iADCs) under which Sutro will receive an upfront cash payment of USD 90 million and may be eligible to receive up to USD 422.5 million in milestones for each product candidate plus tiered royalties.
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