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线粒体形态的研究更多地是在培养的细胞而不是天然细胞中进行的。The issue with this disparity has been highlighted by a study of vascular smooth muscle cells, of which those that were cultured cells appeared to offer more mitochondrial morphological diversity than in those that are native, which rather have singular spherical or rod-like mitochondria (with native cells in most tissues being found to have these similar, punctuate mitochondria), making it unlikely that observing ovoid shapes is due to氧化应激或成像难度。进一步的证据表明，遵守线粒体形状的传统观念包括未发现天然细胞的线粒体是电耦合的 - 它们的膜电位变化是独立的，而不是作为公共变化的一部分，这将在形成连续网络的细胞器中观察到。图1介绍了这项研究中线粒体和培养细胞中线粒体的图像。
1线粒体总是显示为椭圆形
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