噬菌体,侵入细菌细胞的病毒是生物圈中最丰富的生物。噬菌体包括具有双链DNA(最常见),单链DNA,单链RNA和双链RNA(最不常见)的病毒。大多数病毒体(96%)是尾巴的;其他类型是立方体,丝状或多态性。噬菌体基因组是由于高频率的水平遗传交换和重组而多样化和普遍的镶嵌性。噬菌体可能具有裂解或裂解生命周期。它们附着在特定细菌上,并通过酶内olysins和holins杀死,而不会因宿主特异性而影响共生微生物。有一个恒定的“进化武器竞赛”,导致竞争性细菌噬菌体的进化。正在开发许多多种多样和复杂的细菌防御机制,以抑制噬菌体生命周期的各个阶段。同时,噬菌体也发展为克服这些细菌防御。正在开发基于噬菌体的治疗方法,其中单噬菌体,噬菌体鸡尾酒,噬菌体衍生的酶,噬菌体与抗生素结合使用,而转基因噬菌体可能有用。这对于用多药耐药(MDR)病原体以及去除生物膜的感染治疗感染可能很有用。新生儿(2023):10.5005/jp-journals-11002-0078Keywords: Abi-associated enzymes, Abortive infection, Adsorption block, Bacteriophage, Bacteriophage exclusion system, Biofilms, Bradley's classification, Carjivirus communis , Caudovirales, Chromosomal islands, Contractile tails, Cosmids, CrAssphage, CRISPER-cas bacterial immune system, Darwinian principles, Double-stranded DNA, Destruction of phage DNA after injection, Diversity-generating retroelements, dsDNA, Endolysin, Enterobacteria P4-like prophages, ESKAPE, Evolutionary arms race, Glucosyl-hydroxymethylcytosine, Helper proteins, Human phageome, Hydroxymethylcytosine, Infant, Lactococcus phage c2, Lit activator gol peptide, Long non-contractile tails, Lytic cycle, Lysogenic cycle, Metagenomics, Mosaicism, MS2 coat, Mycoplasma phage P1, Myoviridae, Neonate, Newborn, P2-like prophages, Pasteurella phage F108, Penetration block, Phage display, Phagemid, Phage coevolution, Phage cocktail, Phage terminase small subunit, Phage anti-restriction-induced system, Phage ecology, Podoviridae, Polyphage, Prophage, Prokaryote viruses, Prokaryotic argonautes, Pseudolysogenic cycle, Receptor, Receptor-binding proteins, Restriction-modification systems, RexAB system, Retrons, Short tails, Siphoviridae, ssRNA, Temperate phage, Toxin-antitoxin systems, Transduction,有毒的噬菌体。
主要关键词