Affiliations: 1 Department of Medicine, Division of Digestive Diseases, Emory University 2 Graduate Program in Biochemistry, Cell and Developmental Biology, Emory University 3 Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore 4 Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore 5 Lead contact: agracz@emory.edu * these authors contributed equally对于手稿,作者没有宣布利益冲突作者贡献:JL,AG和ADG对实验进行了想法和设计。JL,AG,FT,SW,TH和ADG进行了实验。nb设计和生成的LGR5-2A-DTR等位基因。JL,AG和ADG编写并编辑了手稿。致谢作者感谢Gracz Lab的成员对手稿的有益对话和批判性审查。这项工作由NIH R35GM142503(GRACZ)和R35GM142503-01S1(GRACZ)资助。这项工作得到了埃默里小鼠转基因和基因靶向核心(TMF)的部分支持,该核心由国家推进NIH的转化科学中心提供了额外的支持(UL1TR000454)。
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