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在最近的试验中证明的SGLT2抑制剂和GLP-1类似物的心血管和肾脏益处值得注意。A recent meta-analysis of these data reported a relative risk reduction (RRR) in atherosclerotic events of 12% and 11% with GLP-1 analogues and SGLT2 inhibitors respectively (almost all of this benefit was observed in patients with established atherosclerotic disease), a RRR of 31% in hospitalisation due to heart failure with SGLT2 inhibitors, and a RRR 18% and 38% in kidney GLP-1类似物和SGLT2抑制剂的疾病进展。SGLT2抑制剂可降低EGFR恶化,终阶段肾脏疾病或肾脏疾病的相对风险相关的死亡。16这些心血管和肾脏作用似乎与血糖控制无关。

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