As published online in Theranostics, the preliminary analyzes of LncRNA & mRNA& miRNA were performed by Novogene, reported that lncRnA, mRNA and small RNA transcriptomes provide insights into the protec- tive effects of rSj16 on DSS-induced colitis, which is mainly mediated by PPAR-α signaling pathway inhibition.rsj16减弱了DSS诱导的结肠炎小鼠的临床活性,促炎性细胞因子的产生,上调上调的免疫调节细胞因子产生以及DSS诱导的结肠炎小鼠的Treg百分比增加。此外,用RSJ16处理的DSS诱导的结肠炎小鼠在结肠中表现出特定基因的表达水平的变化,并显示了过氧化物酶体增殖物激活受体α(PPAR-α)信号传导途径的关键作用。pPAR-α激活减少了DSS诱导的结肠炎小鼠RSJ16的治疗方法,表明PPAR-α信号通路在DSS诱导的结肠炎开发中起着至关重要的作用。该研究的发现RSJ16可能有助于RSJ16可以作为Thepeatiutiut te Trapeiutiation ppar-α有用。
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