方法:在此第2阶段,开放标签研究中,23例轻度认知障碍或轻度痴呆症患者每天两次接受20毫克口服NE3107,持续3个月。主要终点评估了使用先进的神经成像分析中神经生理健康和氧化应激(谷胱甘肽水平)中基线的变化。Secondary endpoints evaluated changes from baseline in neuropsychological health using cognitive assessments, including the 11-item Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog11), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment, Clinical Dementia Rating, Quick Dementia Rating Scale, Alzheimer's Disease Composite Score, and Global Rating of Change (GRC)。探索性终点评估了神经炎症生物标志物(肿瘤坏死因子α,TNF-α)和AD(淀粉样蛋白β和磷酸化tau [p-tau])的基线变化。
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