结论：已经开发了一种新型的Tofacitinib LC-MS/MS分析。探索了测量生化依从性的分析的影响。需要进一步的研究，以确定测定的敏感性和测定能力检测不遵守的能力。参考文献：[1] Alten R，KrügerK，Rellecke J，Schiffner-Rohe J，Behmer O，Schiffhorst G等。使用离散选择方法检查患者在类风湿关节炎治疗中的偏好。患者更喜欢依从性。2016; 10：2217-28。 [2] Suzuki M，Tse S，Hirai M，Kurebayashi Y. 将基于生理的药代动力学建模应用于日语预测tofacitinib的预测。 Kobe J Med Sci。 2017; 62（6）：E150-E61。 Acknowledgements: Financial support was provided as an Investigator Spon- sored Research Grant from Pfizer Limited Disclosure of Interests: Stephanie Church Grant/research support from: Finan- cial support was provided as an Investigator Sponsored Research Grant from Pfizer Limited, Kimme Hyrich Speakers bureau: Honoraria as a speaker received from Abbvie, Grant/research support from: Financial support was provided as an Investigator Sponsored Research Grant from Pfizer 有限的。 AB在过去的12个月中获得了Scipher Medicine Ltd，Bristol Myers Squibb和Gal-Apagos的赠款。James Bluett Grant/Research Support in：Fanancial Support：Fanancial Support是作为调查员的PFISER LIM-IS提供的调查人员赞助研究赠款。 JB已从UCB，辉瑞和Eli Lilly Doi获得旅行/会议费：10.1136/Annrheumdis-2022-Eular.2422016; 10：2217-28。[2] Suzuki M，Tse S，Hirai M，Kurebayashi Y.将基于生理的药代动力学建模应用于日语预测tofacitinib的预测。Kobe J Med Sci。 2017; 62（6）：E150-E61。 Acknowledgements: Financial support was provided as an Investigator Spon- sored Research Grant from Pfizer Limited Disclosure of Interests: Stephanie Church Grant/research support from: Finan- cial support was provided as an Investigator Sponsored Research Grant from Pfizer Limited, Kimme Hyrich Speakers bureau: Honoraria as a speaker received from Abbvie, Grant/research support from: Financial support was provided as an Investigator Sponsored Research Grant from Pfizer 有限的。 AB在过去的12个月中获得了Scipher Medicine Ltd，Bristol Myers Squibb和Gal-Apagos的赠款。James Bluett Grant/Research Support in：Fanancial Support：Fanancial Support是作为调查员的PFISER LIM-IS提供的调查人员赞助研究赠款。 JB已从UCB，辉瑞和Eli Lilly Doi获得旅行/会议费：10.1136/Annrheumdis-2022-Eular.242Kobe J Med Sci。2017; 62（6）：E150-E61。 Acknowledgements: Financial support was provided as an Investigator Spon- sored Research Grant from Pfizer Limited Disclosure of Interests: Stephanie Church Grant/research support from: Finan- cial support was provided as an Investigator Sponsored Research Grant from Pfizer Limited, Kimme Hyrich Speakers bureau: Honoraria as a speaker received from Abbvie, Grant/research support from: Financial support was provided as an Investigator Sponsored Research Grant from Pfizer 有限的。 AB在过去的12个月中获得了Scipher Medicine Ltd，Bristol Myers Squibb和Gal-Apagos的赠款。James Bluett Grant/Research Support in：Fanancial Support：Fanancial Support是作为调查员的PFISER LIM-IS提供的调查人员赞助研究赠款。 JB已从UCB，辉瑞和Eli Lilly Doi获得旅行/会议费：10.1136/Annrheumdis-2022-Eular.2422017; 62（6）：E150-E61。Acknowledgements: Financial support was provided as an Investigator Spon- sored Research Grant from Pfizer Limited Disclosure of Interests: Stephanie Church Grant/research support from: Finan- cial support was provided as an Investigator Sponsored Research Grant from Pfizer Limited, Kimme Hyrich Speakers bureau: Honoraria as a speaker received from Abbvie, Grant/research support from: Financial support was provided as an Investigator Sponsored Research Grant from Pfizer 有限的。AB在过去的12个月中获得了Scipher Medicine Ltd，Bristol Myers Squibb和Gal-Apagos的赠款。James Bluett Grant/Research Support in：Fanancial Support：Fanancial Support是作为调查员的PFISER LIM-IS提供的调查人员赞助研究赠款。JB已从UCB，辉瑞和Eli Lilly Doi获得旅行/会议费：10.1136/Annrheumdis-2022-Eular.242Research grant award from BMS, Kayode Ogungbenro Consultant of: Afferent, Biogen, Buzzard, Grant/research support from: Financial support was provided as an Investi- gator Sponsored Research Grant from Pfizer Limited., Richard Unwin Grant/research support from: Financial support was provided as an Investigator Sponsored Research Grant from Pfizer Limited, Anne Barton Grant/research support from: Financial support was provided as an Investigator Sponsored Research Grant from Pfizer 有限的。