ATRX-在基因表达调节BRAF V600E中起关键作用 - 在高级神经胶质瘤中很少发现。在小儿种群TERT - 端粒酶逆转录酶中常见;突变时,允许无限的增殖激活;预后/存活率不佳所指出的EGFR - 表皮生长因子受体;在许多癌症中发现与预后不良有关的高EGFR表达 - 一种细胞中的蛋白质,当细胞准备分裂时会增加,而当过表达1p / 19q时,可能会预测预后不良 - 在寡头胶状胶质瘤中可见骨骼。与对化学疗法的更好反应和改善的生存IDH - 异位酸盐脱氢酶 - 阳性与低级肿瘤一致; Associated with a more favorable prognosis TP53 - plays a role in apoptosis and suppresses the cell cycle Involved in triggering the development and spread of glioblastoma MGMT - O6-methylguanine methyltransferase - involved in repairing DNA damage in cancer cells Tumor Mutational Burden TMB – refers to the total amount of cancer tissue in the body found in <3% of glioblastoma patients Microsatellite Instability – MSI-由MMR系统中的缺陷引起的,负责校正DNA复制过程中发生的不匹配。
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