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有证据表明，肠道微生物组的产后发育有助于儿童营养不良1-4。在这里，我们分析了来自微生物组指导的互补食品（MDCF-2）的随机对照试验的生物测量，该试验与在12-18个月大的班加拉德岛（12-18个月大的邦格拉德郡儿童中）相比，与热量更密集的常规辅助食品相比，其体重增加率较高。We reconstructed 1,000 bacterial genomes (metagenome-assembled genomes (MAGs)) from the faecal microbiomes of trial participants, identified 75 MAGs of which the abundances were positively associated with ponderal growth (change in weight-for-length Z score (WLZ)), characterized changes in MAG gene expression as a function of treatment type and WLZ response, and quantified carbohydrate MDCF-2和粪便中的结构。结果表明，与WLZ正相关的两个Prevotella copri mag是MDCF-2诱导的代谢途径表达的主要贡献者，该代谢途径涉及使用MDCF-2的成分聚糖。The predicted specificities of carbohydrate-active enzymes expressed by their polysaccharide- utilization loci are correlated with (1) the in vitro growth of Bangladeshi P. copri strains, possessing varying degrees of polysaccharide-utilization loci and genomic conservation with these MAGs, in defined medium containing different purified glycans representative of those in MDCF-2, and （2）试验参与者中粪便碳水化合物结构的水平。这些关联表明，通过与生长相关的细菌分类群代谢的MDCF中鉴定生物活性聚糖结构将有助于指导有关其在急性营养不良儿童中使用的建议，并能够开发出其他配方。
在微生物组指导的食物中，生物活性糖
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