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• Slowed growth • Loss of purposeful hand movement, replaced by compulsive hand motions • Loss of muscle tone • Cognitive delay and intellectual disability • Decreased verbal skills, loss of verbal ability • Problems with movement, coordination, spasticity • Difficulty chewing, swallowing, impaired stomach emptying, teeth grinding • Skin breakdown caused by hands in mouth • Breathing difficulties like apnea, hyperventilation • Scoliosis •复发性耳朵感染•癫痫发作无法治愈卢比。治疗方法专注于管理症状，协助沟通和减慢能力的丧失。治疗可能包括抗塞氏菌药物，监测和治疗骨骼健康，心脏病管理，喂养疗法，胃肠道和营养管理以及PT/OT/SLP。
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